The yeast will both eat the wort and create their own flavour profile, which might mix together well or not, try it out and see.
Some of my best beers have been using mixed yeasts...
Not sure about using lager yeasts at high temps in a mix though, they do tend to create a bit of sulphur which can take some time to fade.
US56 and S-33 is pretty good, not sure about US56 and SO4 together but it might be OK. My favourite is US56 and White Labs 36 Alt strain, good attenuation, nice profile for APA's and most other ales and still clean up to 20C.