Depends what you're into mate
Melbourne has the best bar scene in Australia. Easily.
Huge variety & plenty of them.
For beer, there are two James Squire brew pubs. Fed Square's Transport or Beer De'Luxe. Plenty of others just outside of CBD.
If you just want a good old fashioned boozer, get into the Great Western on King St (CUB only). Probably the last country style pub in Melbourne CBD.
If you want to combine good old boozer with big screen sport. Get to the Charles Dickens hotel.
If you want a cool time with plenty of young things about, try St Jeromes, Section 8, Workshop, Cherry Bar, Ding Dong, Pony, etc etc
Plenty of bogus Irish pubs around as well
Word from the wise.
- Crown Casino is the most overated venue of all time, anywhere in the world. Dont go, ever. (IMHO)
- Stay off King St, except for the GW (or if your strip bars, in which case you'll need to go directly here)
- Anything with a bouncer or a queue is a bad idea
Cheers
Paul