OK, so I could run a dual OS like you do, and use Fedora/Linux/whatever for all apps except those that are Windows Specific (like my audio gear, and photoshop). That would mean no 'cross-contamination' if Im surfing the net with Linux ?
I'm really being sold on this idea.
Just in case you've misunderstood something here, I'll clarify - 'dual booting' means you have two options when you 'boot' (start up) your computer. You either start in Linux, or in Windows. There's no great way to have them both run independently at the same time (there are ways, they're just not great). It's not as simple as surfing the net in Linux while photoshopping in Windows.
What Wine does is creates a sort of 'little Windows environment' while you're running Linux - it creates a temporary filesystem with all the system files you should need to run a Windows program. In this case, the risk of infection is minimal, since you can just delete the little Windows filesystem should it get infected (Wine may even do this every time by default), and the Linux filesystem is reasonably impervious to virus attacks (permissions on every file FTW!).
If you dual boot, when you turn on the machine you choose which OS you want to use. If you have specific software in different OSs, you need to boot into them one at a time. I've done this for a long time, and it's no real hassle. Windows to use a symbolic algebra program I had, but everything else in Ubuntu. Eventually, the math program was made for Linux, so now I hardly ever boot into M$. There are heaps of free programs under Linux for almost anything you could want to do, and software companies are starting to make Linux versions of some software.
There's a chance that your audio software will work in Linux. I've heard of getting Photoshop going too. As someone previously suggested, get a LiveCD (I recommend Ubuntu - great hardware support now) and test out the machine. You can probably even test out Windows software under Wine (I believe it is installed on the LiveCD) - you just won't be able to keep anything after you shutdown. A LiveCD is an even more miraculous version of the 'little Windows environment' - it's a 'little Linux environment' that gets installed essentially in the RAM (memory). You can run it with no hard-drive in the machine. It does
nothing to your Windows files, and is a great way to see what an OS can do.
Good luck with it all!