Clutch...
Here are your options.
Brewboys,
Wheatsheaf
or if you have to be in the city,
The Kings.
The first 2 choices are about as far away from propect as each other. Brewboys is local micro and is nice and chilled. Wheatsheaf is the best australia can import and also aussie micro.
Start at the kings, have 2 beers, take the tram to the wheatsheaf (it's free), have a few beers, take a taxi to brewboys, have a few beers and then take a taxi back home/bed...good slice of SA beer and other quality brews mate.
Don't go port dock or holdfast unless you like vb.
Cheers