Really open ended question, I think the answer comes down to the quality of your crush.
Have done 100% wheat in a Braumeister (an exercise in patience), had to crack very carefully to avoid flour, about 4 times through the mill starting at just touching the malt and getting progressively finer each pass until you get a nearly dust free kibble.
50/50 Wheat and Pilsner shouldn't be a problem but I would crack the malts separately, aim for opened up but not shredded husks from the pilsner and kibble from the wheat.
I brewed a Piwo Grosziskie last week, 3kg of smoked wheat (100% of grains) with 300 g of rice hulls. Milled at .85mm gap width. No problem with the lauter
Half-baked
I keep sticking my face in the smoked wheat bucket, I love the smell but haven't had a go at it yet.
Would love to hear how the brew turns out, which yeast did you go with? I've been thinking about trying with W1007 German Ale, but would be interested in other options.
Looks like a brew that is really well suited to BIAB, mash in heavy (2-2.5:1) for a protein rest, hot water additions to saccharification temperature, then to mash out, for a 3% beer there is plenty of room for water additions.
Why not start a thread on the style, its certainly interesting enough.
Mark